Fast synthesis of aryl triflates with controlled microwave heating

被引：50

作者：

Bengtson, A ^{[1
]}

Hallberg, A ^{[1
]}

Larhed, M ^{[1
]}

机构：

[1] Uppsala Univ, Dept Organ Pharmaceut Chem, BMC, SE-75123 Uppsala, Sweden

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 07期

关键词：

D O I：

10.1021/ol025701a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Synthesis of aryl triflates from phenols using N-phenyltriflimide requires only 6 min for completion when conducted with controlled microwave heating. The methodology was applied to both solution- and solid-phase conditions. Ten different aryl triflates were synthesized and isolated in good yields. Applications in high-throughput chemistry are suggested.

引用

页码：1231 / 1233

页数：3

共 11 条

[1] Chemical transformations induced by triflic anhydride
Baraznenok, IL
Nenajdenko, VG
Balenkova, ES
[J]. TETRAHEDRON, 2000, 56 (20) : 3077 - 3119
[2] BARLOS K, 1991, INT J PEPT PROT RES, V37, P513
[3] Preparation of functionalised aryl alkynes as precursors to extended cyclophanes
Crisp, GT
Turner, PD
[J]. TETRAHEDRON, 2000, 56 (03) : 407 - 415
[4] Dielectric parameters relevant to microwave dielectric heating
Gabriel, C
Gabriel, S
Grant, EH
Halstead, BSJ
Mingos, DMP
[J]. CHEMICAL SOCIETY REVIEWS, 1998, 27 (03) : 213 - 223
[5] HENDRICKSON JB, 1973, TETRAHEDRON LETT, V46, P4607
[6] Microwave-assisted high-speed chemistry: a new technique in drug discovery
Larhed, M
Hallberg, A
[J]. DRUG DISCOVERY TODAY, 2001, 6 (08) : 406 - 416
[7] Increasing rates of reaction: Microwave-assisted organic synthesis for combinatorial chemistry
Lew, A
Krutzik, PO
Hart, ME
Chamberlin, AR
[J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2002, 4 (02): : 95 - 105
[8] Microwave assisted organic synthesis -: a review
Lidström, P
Tierney, J
Wathey, B
Westman, J
[J]. TETRAHEDRON, 2001, 57 (45) : 9225 - 9283
[9] RITTER K, 1993, SYNTHESIS-STUTTGART, P735
[10] ATTEMPTS AT SOLVOLYTIC GENERATION OF ARYL CATIONS
SUBRAMANIAN, LR
HANACK, M
CHANG, LWK
IMHOFF, MA
SCHLEYER, PV
EFFENBERGER, F
KURTZ, W
STANG, PJ
DUEBER, TE
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (26) : 4099 - 4103

← 1 2 →