Omega-3 Fatty Acids EPA and DHA: Health Benefits Throughout Life

被引:1136
作者
Swanson, Danielle [1 ]
Block, Robert [2 ,3 ]
Mousa, Shaker A. [1 ,4 ]
机构
[1] Albany Coll Pharm & Hlth Sci, Pharmaceut Res Inst, Rensselaer, NY USA
[2] Univ Rochester, Dept Community & Prevent Med, Sch Med & Dent, Rochester, NY USA
[3] Univ Rochester, Sch Med & Dent, Dept Med, Div Cardiol, Rochester, NY 14642 USA
[4] King Saud Univ, Coll Med, Riyadh 11461, Saudi Arabia
关键词
POLYUNSATURATED FATTY-ACIDS; RANDOMIZED-CONTROLLED-TRIAL; FISH-OIL SUPPLEMENTATION; PLACEBO-CONTROLLED TRIAL; CORONARY-ARTERY-DISEASE; ALPHA-LINOLENIC ACID; DOCOSAHEXAENOIC ACID; ALZHEIMERS-DISEASE; DOUBLE-BLIND; EICOSAPENTAENOIC ACID;
D O I
10.3945/an.111.000893
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 [营养与食品卫生学];
摘要
Omega-3 [(n-3)] fatty acids have been linked to healthy aging throughout life. Recently, fish-derived omega-3 fatty acids EPA and DHA have been associated with fetal development, cardiovascular function, and Alzheimer's disease. However, because our bodies do not efficiently produce some omega-3 fatty acids from marine sources, it is necessary to obtain adequate amounts through fish and fish-oil products. Studies have shown that EPA and DHA are important for proper fetal development, including neuronal, retinal, and immune function. EPA and DHA may affect many aspects of cardiovascular function including inflammation, peripheral artery disease, major coronary events, and anticoagulation. EPA and DHA have been linked to promising results in prevention, weight management, and cognitive function in those with very mild Alzheimer's disease. Adv. Nutr. 3: 1-7, 2012.
引用
收藏
页码:1 / 7
页数:7
相关论文
共 56 条
[1]
Effect of eicosapentaenoic and docosahexaenoic acid on resting and exercise-induced inflammatory and oxidative stress biomarkers: a randomized, placebo controlled, cross-over study [J].
Bloomer, Richard J. ;
Larson, Douglas E. ;
Fisher-Wellman, Kelsey H. ;
Galpin, Andrew J. ;
Schilling, Brian K. .
LIPIDS IN HEALTH AND DISEASE, 2009, 8
[2]
Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells [J].
Bouwens, Mark ;
van de Rest, Ondine ;
Dellschaft, Neele ;
Bromhaar, Mechteld Grootte ;
de Groot, Lisette C. P. G. M. ;
Geleijnse, Johanna M. ;
Muller, Michael ;
Afman, Lydia A. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2009, 90 (02) :415-424
[3]
Cawood AL, 2010, ATHEROSCLEROSIS, V212, P252, DOI 10.1016/j.atherosclerosis.2010.05.022
[4]
The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: A preliminary randomized double-blind placebo-controlled study [J].
Chiu, Chih-Chiang ;
Su, Kuan-Pin ;
Cheng, Tsung-Chi ;
Liu, Hsing-Cheng ;
Chang, Ching-Jui ;
Dewey, Michael E. ;
Stewart, Robert ;
Huang, Shih-Yi .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2008, 32 (06) :1538-1544
[5]
Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment [J].
Conquer, JA ;
Tierney, MC ;
Zecevic, J ;
Bettger, WJ ;
Fisher, RH .
LIPIDS, 2000, 35 (12) :1305-1312
[6]
Omega-3 fatty acid supplementation improves vascular function and reduces inflammation in obese adolescents [J].
Dangardt, Frida ;
Osika, Walter ;
Chen, Yun ;
Nilsson, Ulf ;
Gan, Li-Ming ;
Gronowitz, Eva ;
Strandvik, Birgitta ;
Friberg, Peter .
ATHEROSCLEROSIS, 2010, 212 (02) :580-585
[7]
n-3 LC-PUFA-enriched dairy products are able to reduce cardiovascular risk factors: A double-blind, cross-over study [J].
Dawczynski, Christine ;
Martin, Lena ;
Wagner, Andreas ;
Jahreis, Gerhard .
CLINICAL NUTRITION, 2010, 29 (05) :592-599
[8]
Dunstan J.A., 2008, ARCH DIS FETAL NEONA, V93, P45
[9]
The effects of fish oil supplementation in pregnancy on breast milk fatty acid composition over the course of lactation: A randomized controlled trial [J].
Dunstan, Janet A. ;
Mitoulas, Leon R. ;
Dixon, Glenys ;
Doherty, Dorota A. ;
Hartmann, Peter E. ;
Simmer, Karen ;
Prescott, Susan L. .
PEDIATRIC RESEARCH, 2007, 62 (06) :689-694
[10]
Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity [J].
Ebrahimi, Mahmoud ;
Ghayour-Mobarhan, Majid ;
Rezaiean, Samaneh ;
Hoseini, Maryam ;
Parizade, Seyyed Mohamad Reza ;
Farhoudi, Fatemeh ;
Hosseininezhad, Syyed Javad ;
Tavallaei, Shima ;
Vejdani, Amirhosein ;
Azimi-Nezhad, Mohsen ;
Shakeri, Mohamad Taghi ;
Rad, Mina Akbari ;
Mobarra, Naser ;
Kazemi-Bajestani, Seyyed Mohammad Reza ;
Ferns, Gordon A. A. .
ACTA CARDIOLOGICA, 2009, 64 (03) :321-327