Differential expression of CYP1A1, CYP1A2, CYP1B1 in human kidney tumours

被引：41

作者：

Cheung, YL

Kerr, AC

McFadyen, MCE

Melvin, WT

Murray, GI ^{[1
]}

机构：

[1] Univ Aberdeen, Dept Pathol, Aberdeen AB25 2ZD, Scotland

[2] Univ Aberdeen, Dept Mol & Cell Biol, Aberdeen AB25 2ZD, Scotland

来源：

CANCER LETTERS | 1999年 / 139卷 / 02期

关键词：

cytochrome P450; Ah receptor; kidney cancer; neoplasm;

D O I：

10.1016/S0304-3835(99)00045-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The presence of mRNA of individual members of the CYP1 gene family in normal and neoplastic kidney has been investigated by RTPCR, CYP1B1 mRNA was consistently expressed in both normal and neoplastic kidney while CYP1A1 was present in the majority of normal and neoplastic whereas CYP1A2 was infrequently expressed. Expression of the Ah receptor and Amt which are involved in the transcriptional activation of the CYP1 genes was also studied, The Ah receptor mRNA and Amt mRNA were consistently expressed both in kidney tumours and normal kidney, These results indicate differential expression of individual members of the CYP1 gene family in normal and neoplastic kidney and suggest that several mechanisms including the Ah receptor complex could be involved in their regulation. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：199 / 205

页数：7

共 23 条

[1] Constitutive activation of the aromatic hydrocarbon receptor
Chang, CY
Puga, A
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (01) : 525 - 535
[2] REGULATION OF CYP1A1 EXPRESSION
FUJIIKURIYAMA, Y
IMATAKA, H
SOGAWA, K
YASUMOTO, KI
KIKUCHI, Y
[J]. FASEB JOURNAL, 1992, 6 (02) : 706 - 710
[3] ROLE OF HUMAN CYTOCHROMES P450 IN THE METABOLIC-ACTIVATION OF CHEMICAL CARCINOGENS AND TOXINS
GONZALEZ, FJ
GELBOIN, HV
[J]. DRUG METABOLISM REVIEWS, 1994, 26 (1-2) : 165 - 183
[4] OXIDATION OF TOXIC AND CARCINOGENIC CHEMICALS BY HUMAN CYTOCHROME-P-450 ENZYMES
GUENGERICH, FP
SHIMADA, T
[J]. CHEMICAL RESEARCH IN TOXICOLOGY, 1991, 4 (04) : 391 - 407
[5] THE ARYL-HYDROCARBON RECEPTOR COMPLEX
HANKINSON, O
[J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1995, 35 : 307 - 340
[6] Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
Hogenesch, JB
Chan, WK
Jackiw, VH
Brown, RC
Gu, YZ
PrayGrant, M
Perdew, GH
Bradfield, CA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (13) : 8581 - 8593
[7] INDUCTION OF CYTOCHROME P4501 AS AN INDICATOR OF POTENTIAL CHEMICAL CARCINOGENESIS
IOANNIDES, C
PARKE, DV
[J]. DRUG METABOLISM REVIEWS, 1993, 25 (04) : 485 - 501
[8] The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: Implications for drug interactions
Kivisto, KT
Kroemer, HK
Eichelbaum, M
[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1995, 40 (06) : 523 - 530
[9] Kovacs G, 1997, J PATHOL, V183, P131, DOI 10.1002/(SICI)1096-9896(199710)183:2<131::AID-PATH931>3.0.CO
[10] 2-G

← 1 2 3 →