Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice

被引：122

作者：

Mercer, JG ^{[1
]}

Moar, KM ^{[1
]}

Rayner, DV ^{[1
]}

Trayhurn, P ^{[1
]}

Hoggard, N ^{[1
]}

机构：

[1] ROWETT RES INST,MOL PHYSIOL GRP,ABERDEEN AB21 9SB,SCOTLAND

来源：

FEBS LETTERS | 1997年 / 402卷 / 2-3期

关键词：

leptin receptor mRNA; arcuate nucleus; ventromedial nucleus; obesity; leptin injection; cold exposure;

D O I：

10.1016/S0014-5793(96)01525-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leptin receptor gene expression has been measured in arcuate and ventromedial hypothalamic nuclei. Receptor mRNA in both hypothalamic areas was higher in obese mice than in lean littermates. Twice daily leptin administration for 7 days profoundly affected food intake, reduced leptin receptor mRNA in the arcuate nucleus, and had a similar effect on neuropeptide Y gene expression. A single leptin injection was ineffective. Exposure of lean mice to cold for 24 h caused an induction of leptin receptor and NPY mRNA which was normalized when animals were returned to the warm. Regulation of receptor gene expression may be an important component in the reading of the leptin signal.

引用

页码：185 / 188

页数：4

共 21 条

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