Differences in left-right axis pathways in mouse and chick: Functions of FGF8 and SHH

被引：246

作者：

Meyers, EN

Martin, GR ^{[1
]}

机构：

[1] Univ Calif San Francisco, Sch Med, Dept Anat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Sch Med, Dept Pediat, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Sch Med, Program Dev Biol, San Francisco, CA 94143 USA

来源：

SCIENCE | 1999年 / 285卷 / 5426期

关键词：

D O I：

10.1126/science.285.5426.403

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A molecular pathway leading to left-right asymmetry in the chick embryo has been described, in which FGF8 is a right determinant and Sonic Hedgehog a left determinant. Here evidence is presented that the Fgf8 and Sonic Hedgehog genes are required for left-right axis determination in the mouse embryo, but that they have different functions from those previously reported in the chick. In the mouse FGF8 is a left determinant and Sonic Hedgehog is required to prevent left determinants from being expressed on the right.

引用

页码：403 / 406

页数：4

共 30 条

[1] Axis development and early asymmetry in mammals [J].