Cystatin C or Creatinine for Detection of Stage 3 Chronic Kidney Disease in Anorexia Nervosa

被引：45

作者：

Delanaye, Pierre ^{[1
]}

Cavalier, Etienne ^{[2
]}

Radermecker, Regis P. ^{[3
]}

Paquot, Nicolas ^{[3
]}

Depas, Gisele ^{[4
]}

Chapelle, Jean-Paul ^{[2
]}

Scheen, Andre J. ^{[3
]}

Krzesinski, Jean-Marie ^{[1
]}

机构：

[1] Univ Liege, Dept Nephrol, Liege, Belgium

[2] Univ Liege, Dept Clin Chem, Liege, Belgium

[3] Univ Liege, Dept Diabet Nutr & Metab Disorders, Liege, Belgium

[4] Univ Liege, Dept Nucl Med, Liege, Belgium

来源：

NEPHRON CLINICAL PRACTICE | 2008年 / 110卷 / 03期

关键词：

Anorexia nervosa; Glomerular filtration rate; Creatinine; Cystatin C;

D O I：

10.1159/000166607

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Patients with anorexia nervosa (AN) are at a high risk of renal failure. Chronic kidney disease (CKD) is often missed in these patients because the serum creatinine is a poor marker of kidney function. We studied the utility of cystatin C to detect renal failure in this population. Method: Twenty-seven AN patients were studied. Glomerular filtration rates (GFR) were measured with the chromium-51-ethylenediaminetetraacetate (Cr-51-EDTA) method. We compared the ability of creatinine and cystatin C to detect stage 3 CKD (GFR below 60 ml/min) by ROC curve analysis. Results: In this cohort, there is no correlation between GFR and serum creatinine, but there is a significant correlation between cystatin C and GFR. By ROC analysis, the cystatin C concentration is better than the serum creatinine concentration for the detection of stage 3 CKD (area under the curve of 0.86 vs. 0.61, p = 0.05). Conclusion: Plasma cystatin C is better than serum creatinine in detecting stage 3 CKD in patients with AN. Copyright (C) 2008 S. Karger AG, Basel

引用

页码：C158 / C163

页数：6

共 37 条

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