Synthesis of a tetrasaccharide substrate of heparanase

被引：40

作者：

Chen, Jianfang ^{[1
]}

Zhou, Ying ^{[1
]}

Chen, Chen ^{[1
]}

Xu, Weichang ^{[1
]}

Yu, Biao ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2008年 / 343卷 / 17期

基金：

中国国家自然科学基金;

关键词：

Heparan sulfate; Synthesis; Heparanase; Glycosylation; Thioglycoside; Trifluoroacetimidate;

D O I：

10.1016/j.carres.2008.06.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A tetrasaccharide, corresponding to the heparan sulfate heparanase substrate, namely beta-D-GIcA(2S)-(1 -> 4)-alpha-D-GIcN(NS,6S)-(1 -> 4)-beta-D-GIcA-(1 -> 4)-alpha-D-GIcN(NS,6S)-OMe, was synthesized in a convergent manner via coupling of a pair of the disaccharide building blocks as a key step. (C) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：2853 / 2862

页数：10

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