Activin as a morphogen in Xenopus mesoderm induction

被引:92
作者
McDowell, N
Gurdon, JB
机构
[1] Wellcome CRC Inst Canc & Dev Biol, Cambridge CB2 1QR, England
[2] Univ Cambridge, Dept Zool, Cambridge, England
基金
英国惠康基金;
关键词
activin; morphogen; mesoderm induction; Xenopus;
D O I
10.1006/scdb.1999.0307
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Activin, a member of the Transforming Growth Factor beta (TGF-beta) superfamily, can behave as a morphogen in cells of the early Xenopus embryo by inducing a range of mesodermal genes in a concentration-dependent manner. This review examines the behaviour of activin as it forms a morphogen gradient. It also discusses how a cell can perceive its position in a concentration gradient in order to activate appropriate mesodermal gene responses.
引用
收藏
页码:311 / 317
页数:7
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