A septum-derived chemorepulsive factor for migrating olfactory interneuron precursors

被引:112
作者
Hu, HY [1 ]
Rutishauser, U [1 ]
机构
[1] CASE WESTERN RESERVE UNIV,SCH MED,DEPT NEUROSCI,CLEVELAND,OH 44106
关键词
D O I
10.1016/S0896-6273(00)80116-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
During mammalian brain development, immature neurons often migrate considerable distances. A dramatic example is the rostral migration of olfactory interneuron precursors from near the septum to the olfactory bulb via a subventricular pathway. Heterotopic transplantations establish that this migration is unidirectional and that guidance cues operate over a considerable distance. The guidance cues for this translocation have not been identified, and the present studies provide evidence that a diffusible chemorepulsive factor, secreted by caudal septum but not by other tissue regions surrounding the pathway, may be involved. This activity is functionally distinct from that produced by factors that influence vertebrate axon outgrowth, such as netrin-1, netrin-2, and collapsin-1/semaphorin-III. The presence of this activity in the floor plate/ventral spinal cord as well as the septum suggests that it may influence other types of cell migration.
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页码:933 / 940
页数:8
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