Pregnancy outcome in women exposed to antiepileptic drugs: Teratogenic role of maternal epilepsy and its pharmacologic treatment

被引：18

作者：

Cassina, Matteo ^{[1
]}

Dilaghi, Arianna ^{[2
]}

Di Gianantonio, Elena ^{[1
]}

Cesari, Elena ^{[3
]}

De Santis, Marco ^{[3
]}

Mannaioni, Guido ^{[4
]}

Pistelli, Alessandra ^{[2
]}

Clementi, Maurizio ^{[1
]}

机构：

[1] Univ Padua, Teratol Informat Serv, Clin Genet Unit, Dept Woman & Child Hlth, Padua, Italy

[2] Azienda Osped Univ Careggi, Ctr Riferimento Reg Tossicol Perinatale, Clin Toxicol Unit, Florence, Italy

[3] Univ Cattolica Sacro Cuore, Telefono Rosso Teratol Informat Serv, Dept Obstet & Gynecol, I-00168 Rome, Italy

[4] Univ Florence, Dept Pharmacol, Florence, Italy

来源：

REPRODUCTIVE TOXICOLOGY | 2013年 / 39卷

关键词：

Epilepsy; Antiepileptic drugs; Pregnancy; Teratogenicity; Birth defects; CONGENITAL-ANOMALIES; MANAGEMENT ISSUES; FOLIC-ACID; MALFORMATIONS; DEFECTS; FETAL; RISK; LAMOTRIGINE; TERATOLOGY; COHORT;

D O I：

10.1016/j.reprotox.2013.04.002

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Infants born to epileptic women treated with antiepileptic drugs (AEDs) have an increased risk of major congenital malformations (MCMs). In order to determine the role of maternal epilepsy we conducted a prospective cohort study on three cohorts of pregnant women: (i) 385 epileptic women treated with AEDs, (ii) 310 non-epileptic women treated with AEDs, (iii) 867 healthy women not exposed to AEDs (control group). The rate of MCMs in the epileptic group (7.7%) was not statistically higher than in the non-epileptic one (3.9%) (p = 0.068). The rate in the first group was higher compared to the control group (p = 0.001), while the rate in the second one was not (p = 0.534). Our data confirm that AEDs therapy is the main cause of the increased risk of malformations in the offspring of epileptic women; however a teratogenic role of the maternal epilepsy itself cannot be excluded. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：50 / 57

页数：8

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