Frameshift mutagenicity and DNA intercalation of 9-amino-2-hydroxyacridine, a rat liver S9 metabolite of 9-aminoacridine

被引：4

作者：

Tomosaka, H

Anzai, K

Hasegawa, E

Horigome, T

Omata, S

机构：

[1] SCI UNIV TOKYO, FAC SCI, DEPT CHEM, SHIMUKU KU, TOKYO 162, JAPAN

[2] NIIGATA UNIV, FAC SCI, DEPT CHEM, NIIGATA 95021, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1996年 / 60卷 / 04期

关键词：

frameshift mutagenicity; DNA intercalation; acridine;

D O I：

10.1271/bbb.60.714

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

9-Amino-2-hydroxyacridine, a rat liver S9 metabolite of 9-aminoacridine (9-AA), was synthesized, and found to have lower frameshift mutagenicity and stronger DNA binding affinity than 9-AA.

引用

页码：714 / 716

页数：3

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