Observation of A2E oxidation products in human retinal lipofuscin

被引：41

作者：

Avalle, LB

Wang, Z

Dillon, JP

Gaillard, ER ^{[1
]}

机构：

[1] No Illinois univ, Dept Chem & Biochem, De Kalb, IL 60115 USA

[2] Columbia Univ, Dept Ophthalmol, New York, NY 10032 USA

来源：

EXPERIMENTAL EYE RESEARCH | 2004年 / 78卷 / 04期

关键词：

A2E; lipofuscin; retinal pigment epithelium;

D O I：

10.1016/j.exer.2003.10.023

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

dSeveral retinal dystrophies are associated with the accumulation of lipofuscin in the retinal pigment epithelium (RPE). The only structurally characterized component of human retinal lipofuscin is the bis-retinoid pyridinium compound A2E. We report here on the observation of a monooxygenated product of A2E in the organic soluble portion of human retinal lipofuscin and in the organic extract of bovine RPE cells that have been fed A2E and irradiated. Liquid chromatography mass spectrometry confirms that the products are identical. This is the first observation of a photoproduct of A2E in human retinal lipofuscin. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：895 / 898

页数：4

共 20 条

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