Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family

被引：198

作者：

Senaldi, G ^{[1
]}

Varnum, BC ^{[1
]}

Sarmiento, U ^{[1
]}

Starnes, C ^{[1
]}

Lile, J ^{[1
]}

Scully, S ^{[1
]}

Guo, J ^{[1
]}

Elliott, G ^{[1
]}

McNinch, J ^{[1
]}

Shaklee, CL ^{[1
]}

Freeman, D ^{[1
]}

Manu, F ^{[1
]}

Simonet, WS ^{[1
]}

Boone, T ^{[1
]}

Chang, MS ^{[1
]}

机构：

[1] Amgen Inc, Amgen Ctr MS152B, Thousand Oaks, CA 91320 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1999年 / 96卷 / 20期

关键词：

D O I：

10.1073/pnas.96.20.11458

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have identified a cytokine of the IL-6 family and named it novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3). NNT-1/BSF-3 cDNA was cloned from activated Jurkat human T cell lymphoma cells. Its sequence predicts a 225-aa protein with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. The gene for NNT-1/BSF-3 is on chromosome 11q13. A murine equivalent to NNT-1/BSF-3 also was identified, which shows 96% homology to human NNT-1/BSF-3. NNT-1/BSF-3 mRNA is found mainly in lymph nodes and spleen. NNT-1/BSF-3 induces tyrosine phosphorylation of glycoprotein 130 (gp130), leukemia inhibitory factor receptor beta, and signal transducer and activator of transcription 3 in the SK-N-MC human neuroblastoma cells. NNT-1/BSF3 shows activities typical of IL-6 family members. In vitro, it supports the survival of chicken embryo motor and sympathetic neurons. In mice, it induces serum amyloid A, potentiates the induction by IL-1 of corticosterone and IL-6, and causes body weight loss and B cell hyperplasia with serum IgG and IgM increase. NNT-1/BSF3 is a gp130 activator with B-cell stimulating capability.

引用

页码：11458 / 11463

页数：6

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