Preventing and Managing the Side Effects of Isotretinoin

被引：113

作者：

Brelsford, Megan ^{[1
]}

Beute, Trisha Clarke ^{[1
]}

机构：

[1] USN, Med Ctr Portsmouth, Dept Dermatol, Portsmouth, VA 23708 USA

来源：

SEMINARS IN CUTANEOUS MEDICINE AND SURGERY | 2008年 / 27卷 / 03期

关键词：

D O I：

10.1016/j.sder.2008.07.002

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Isotretinoin (1 3-cis-retinoic acid) is widely used for the treatment of severe acne as well as for disorders of conification, for psoriasis, and for skin cancer prevention. As a member of the retinoid family, it has a wide spectrum of side effects, including reproductive, cutaneous, ocular, neurological, musculoskeletal, and hepatic. As long as patients are able to tolerate these side effects, it can be a very effective treatment option. This article examines both the most common and the most concerning side effects as well as ways in which providers and patients may best manage them to be able to benefit from isotretinoin treatment. Semin Cutan Med Surg 27:197-206 (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：197 / 206

页数：10

共 79 条

[1] A proposed set of new guidelines for routine blood tests during isotretinoin therapy for acne vulgaris [J].

Altman, RS ;

Altman, LJ ;

Altman, JS .

DERMATOLOGY, 2002, 204 (03) :232-235

[2] The safety of statins in clinical practice [J].

Armitage, Jane .

LANCET, 2007, 370 (9601) :1781-1790

[3] ISOTRETINOIN THERAPY FOR ACNE-VULGARIS - A REEVALUATION OF THE NEED FOR MEASUREMENTS OF PLASMA-LIPIDS AND LIVER-FUNCTION TESTS [J].

BARTH, JH ;

MACDONALDHULL, SP ;

MARK, J ;

JONES, RG ;

CUNLIFFE, WJ .

BRITISH JOURNAL OF DERMATOLOGY, 1993, 129 (06) :704-707

[4]

Bays Harold E, 2008, Expert Rev Cardiovasc Ther, V6, P391, DOI 10.1586/14779072.6.3.391

[5] Isotretinoin, pregnancies, abortions and birth defects:: a population-based perspective [J].

Berard, Anick ;

Azoulay, Laurent ;

Koren, Gideon ;

Blais, Lucie ;

Perreault, Sylvie ;

Oraichi, Driss .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2007, 63 (02) :196-205

[6] TREATMENT WITH 13-CIS-RETINOIC ACID IN TRANSFUSION-DEPENDENT PATIENTS WITH MYELODYSPLASTIC SYNDROME AND DECREASED TOXICITY WITH ADDITION OF ALPHA-TOCOPHEROL [J].

BESA, EC ;

ABRAHM, JL ;

BARTHOLOMEW, MJ ;

HYZINSKI, M ;

NOWELL, PC .

AMERICAN JOURNAL OF MEDICINE, 1990, 89 (06) :739-747

[7]

Bettoli V, 2005, J AM ACAD DERMATOL, V52, pP21

[8] Isotretinoin: a state-of-the-art conference [J].

Bickers, DR ;

Saurat, JH .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2001, 45 (05) :S125-S128

[9]

Bozkurt B, 2002, EUR J OPHTHALMOL, V12, P173

[10] Functional brain imaging alterations in acne patients treated with isotretinoin [J].

Bremner, JD ;

Fani, N ;

Ashraf, A ;

Votaw, JR ;

Brummer, ME ;

Cummins, T ;

Vaccarino, V ;

Goodman, MM ;

Reed, L ;

Siddiq, S ;

Nemeroff, CB .

AMERICAN JOURNAL OF PSYCHIATRY, 2005, 162 (05) :983-991

← 1 2 3 4 5 6 7 8 →