Preparation of lithium 5-lithiomethyl-3-methylpyrazole-1-carboxylate and its reaction with α-oxoketene dithioacetals:: A new general method for substituted and annelated pyrazolo[1,5-a] pyridines

被引：22

作者：

Kishore, K

Reddy, KR

Suresh, JR

Ila, H ^{[1
]}

Junjappa, H

机构：

[1] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India

[2] NE Hill Univ, Dept Chem, Shillong 793003, Meghalaya, India

来源：

TETRAHEDRON | 1999年 / 55卷 / 24期

关键词：

D O I：

10.1016/S0040-4020(99)00380-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Methylpyrazole derivative 1 is metallated at the C-5 methyl carbon atom to form lithium 5-lithiomethyl-3-methylpyrazole-1-carboxylate 3 which on reaction with alpha-oxoketene dithioacetals 4a-d, 12a-c and 15a-b yields substituted and annelated pyrazolo[1,5-n]pyridines 7a-d, 13a-c and 16a-b. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7645 / 7652

页数：8

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