Carnisone increases efficiency of DOPA therapy of Parkinson's disease: A pilot study

被引：94

作者：

Boldyrev, Alexander ^{[1
,2
]}

Fedorova, Tatiana ^{[2
]}

Stepanova, Maria ^{[2
]}

Dobrotvorskaya, Irina ^{[2
]}

Kozlova, Eugenia ^{[2
]}

Boldanova, Natalia ^{[1
,3
]}

Bagyeva, Gulbakhar ^{[2
]}

Ivanova-Smolenskaya, Irina ^{[2
]}

Illarioshkin, Serguey ^{[2
]}

机构：

[1] Moscow MV Lomonosov State Univ, Sch Biol, Int Biotechnol Ctr, Moscow 119992, Russia

[2] Russian Acad Med Sci, Res Ctr Neurol, Moscow, Russia

[3] Russian Acad Sci, Baykal Inst Nat Resources, Siberian Branch, Ulan Ude, Russia

来源：

REJUVENATION RESEARCH | 2008年 / 11卷 / 04期

关键词：

D O I：

10.1089/rej.2008.0716

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The addition of the neuropeptide carnosine (beta-alanyl-L-histidine) as a food additive to the basic protocol of Parkinson's disease treatment results in significant improvement of neurological symptoms, along with increase in red blood cell Cu/Zn-SOD and decrease in blood plasma protein carbonyls and lipid hydroperoxides, with no noticeable change in platelets MAO B activity. The combination of carnosine with basic therapy may be a useful way to increase efficiency of PD treatment.

引用

页码：821 / 827

页数：7

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