Within-session determination of dose-response curves for heroin self-administration in rats: Comparison with between-session determination and effects of naltrexone

被引:33
作者
Martin, TJ
Walker, LE
Sizemore, GM
Smith, JE
Dworkin, SI
机构
[1] Ctr. Neurobiological Invest. Drug A., Dept. of Physiology and Pharmacology, Bowman Gray School of Medicine, Winston-Salem, NC 27157-1083, Medical Center Blvd.
关键词
heroin; naltrexone; self-administration; dose-response; antagonism;
D O I
10.1016/0376-8716(96)01245-8
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
A procedure was employed in the present study to obtain dose-response curves for heroin self-administration within each experimental session. The data generated rising this procedure were compared to dose-response data obtained using between-session dose manipulations. The dose of heroin (18, 30, 60 or 100 mu g/kg/int) was varied across 4-hourly segments separated by a 20-min time-out period during which heroin was not available. The within-session dose-response procedure yielded data similar to those obtained using between-session dose manipulations when the order of dose presentation was increasing or random. However, the dose-response curve for total drug intake was flat when the doses were presented in decreasing order. Further analysis of the dose-response curves in the within-session procedure demonstrated that the rate of heroin intake increased in the third and fourth hourly components compared to the first component, suggesting acute tolerance to the reinforcing and/or rate-suppressive effects of heroin. Furthermore, using a random order of dose presentation, administration of 3.0 mg/kg of naltrexone prior to the session shifted the dose-response curve for heroin self-administration 5-fold to the right in the within-session procedure. The data indicate that the within-session dose-response procedure can be used to investigate the pharmacology of heroin self-administration in rodents.
引用
收藏
页码:93 / 100
页数:8
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