Human foamy virus replication: A pathway distinct from that of retroviruses and hepadnaviruses

被引:223
作者
Yu, SF
Baldwin, DN
Gwynn, SR
Yendapalli, S
Linial, ML
机构
[1] FRED HUTCHINSON CANC RES CTR,DIV BASIC SCI,SEATTLE,WA 98104
[2] UNIV WASHINGTON,DEPT MICROBIOL,SEATTLE,WA 98195
[3] UNIV WASHINGTON,INTERDISCIPLINARY PROGRAM MOLEC & CELLULAR BIOL,SEATTLE,WA 98195
关键词
D O I
10.1126/science.271.5255.1579
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Human foamy virus (HFV) is the prototype of the Spumavirus genus of Retroviridae. In all other retroviruses, the pol gene products, including reverse transcriptase, are synthesized as Gag-Pol fusion proteins and are cleaved to functional enzymes during viral budding or release, In contrast, the Pol protein of HFV is translated from a spliced messenger RNA and lacks Gag domains, Infectious HFV particles contain double-stranded DNA similar in size to full-length provirus, suggesting that reverse transcription has taken place in viral particles before new rounds of infection, reminiscent of hepadnaviruses. These data suggest that foamy viruses possess a replication pathway containing features of both retroviruses and hepadnaviruses but distinct from both.
引用
收藏
页码:1579 / 1582
页数:4
相关论文
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