DNA sensing unchained

被引：15

作者：

Ablasser, Andrea ^{[1
]}

Hornung, Veit ^{[1
]}

机构：

[1] Univ Bonn, Univ Hosp, Inst Clin Chem & Pharmacol, Unit Clin Biochem, Bonn, Germany

来源：

CELL RESEARCH | 2013年 / 23卷 / 05期

关键词：

INNATE IMMUNE SENSOR; CYCLIC GMP-AMP;

D O I：

10.1038/cr.2013.28

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In two recent reports in Science, James Chen and colleagues provide compelling evidence that detection of cytosolic DNA triggers the production of a novel second messenger, cyclic GMP-AMP (cGAMP), which in turn activates a signaling pathway that induces type I interferons (IFNs) in a STING-dependent manner. They further unravel a key role for a so far uncharacterized murine protein E330016A19 (human homolog: C6ORF150), now termed cGAMP synthetase (cGAS), to act as the DNA sensor that generates cGAMP.

引用

页码：585 / 587

页数：3

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