Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy

被引：241

作者：

Marchetti, Giulia ^{[1
]}

Bellistri, Giusi M. ^{[1
]}

Borghi, Elisa ^{[2
]}

Tincati, Camilla ^{[1
]}

Ferramosca, Stefania ^{[3
]}

La Francesca, Maria ^{[2
]}

Morace, Giulia ^{[2
]}

Gori, Andrea ^{[4
]}

Monforte, Antonella d'Arminio ^{[1
]}

机构：

[1] Univ Milan, San Paolo Hosp, Clin Infect Dis, Dept Med Surg & Dent, I-20142 Milan, Italy

[2] Univ Milan, Dept Publ Hlth, I-20142 Milan, Italy

[3] Univ Milan, Luigi Sacco Hosp, Chair Infect Dis & Trop Med, Dept Clin Sci, I-20142 Milan, Italy

[4] San Gerardo Hosp, Div Infect Dis, Monza, Italy

来源：

AIDS | 2008年 / 22卷 / 15期

关键词：

D O I：

10.1097/QAD.0b013e3283112d29

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Patients with inefficient (CD4+ T-cell recovery on virogically suppressive highly active antiretroviral therapy constitute a major clinical hurdle given the threat of HIV/AIDS disease progression. We show heightened circulating lipopolysaccharide associated with plasma enterobacterial DNA and highly activated Ki67+CD4+CD8+ in 24 immunologic-nonresponders (CD4+ T-cell <= 200; HIV-RNA <= 50) compared with 11 full responders (CD4+ T-cell >= 400; HIV-RNA <= 50). These data provide novel insight into INRs pathogenesis, since they correlate augmented systemic translocation of microbial bioproducts with T-cell hyperactivation.

引用

页码：2035 / 2038

页数：4

共 20 条

[1] Incomplete CD4 T cell recovery in HIV-1 infection after 12 months of highly active antiretroviral therapy is associated with ongoing increased CD4 T cell activation and turnover [J].

Anthony, KB ;

Yoder, C ;

Metcalf, JA ;

DerSimonian, R ;

Orenstein, JM ;

Stevens, RA ;

Falloon, J ;

Polis, MA ;

Lane, HC ;

Sereti, I .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2003, 33 (02) :125-133

[2]

BENAMOR K, 2008, DISTURBED GUT MICROB

[3] Microbial translocation is a cause of systemic immune activation in chronic HIV infection [J].

Brenchley, Jason M. ;

Price, David A. ;

Schacker, Timothy W. ;

Asher, Tedi E. ;

Silvestri, Guido ;

Rao, Srinivas ;

Kazzaz, Zachary ;

Bornstein, Ethan ;

Lambotte, Olivier ;

Altmann, Daniel ;

Blazar, Bruce R. ;

Rodriguez, Benigno ;

Teixeira-Johnson, Leia ;

Landay, Alan ;

Martin, Jeffrey N. ;

Hecht, Frederick M. ;

Picker, Louis J. ;

Lederman, Michael M. ;

Deeks, Steven G. ;

Douek, Daniel C. .

NATURE MEDICINE, 2006, 12 (12) :1365-1371

[4] Enteric bacteria, lipopolysaccharides and related cytokines in inflammatory bowel disease: biological and clinical significance [J].

Caradonna, L ;

Amati, L ;

Magrone, T ;

Pellegrino, NM ;

Jirillo, E ;

Caccavo, D .

JOURNAL OF ENDOTOXIN RESEARCH, 2000, 6 (03) :205-214

[5] Increased levels of activated subsets of CD4 T cells add to the prognostic value of low CD4 T cell counts in a cohort of HIV-infected drug users [J].

Carbone, J ;

Gil, J ;

Benito, JM ;

Navarro, J ;

Muñóz-Fernández, A ;

Bartolomé, J ;

Zabay, JM ;

López, F ;

Fernández-Cruz, E .

AIDS, 2000, 14 (18) :2823-2829

[6] LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation [J].

Cooke, KR ;

Gerbitz, A ;

Crawford, JM ;

Teshima, T ;

Hill, GR ;

Tesolin, A ;

Rossignol, DP ;

Ferrara, JLM .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (12) :1581-1589

[7]

Douek Daniel C., 2003, AIDS Reviews, V5, P172

[8] Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy [J].

Fleury, S ;

Rizzardi, GP ;

Chapuis, A ;

Tambussi, G ;

Knabenhans, C ;

Simeoni, E ;

Meuwly, JY ;

Corpataux, JM ;

Lazzarin, A ;

Miedema, F ;

Pantaleo, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (10) :5393-5398

[9] Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis [J].

Gori, Andrea ;

Tincati, Camilla ;

Rizzardini, Giuliano ;

Torti, Carlo ;

Quirino, Tiziana ;

Haarman, Monique ;

Ben Amor, Kaouther ;

van Schaik, Jacqueline ;

Vriesema, Aldwin ;

Knol, Jan ;

Marchetti, Giulia ;

Welling, Gjalt ;

Clerici, Mario .

JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (02) :757-758

[10] Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy [J].

Hunt, Peter W. ;

Brenchley, Jason ;

Sinclair, Elizabeth ;

McCune, Joseph M. ;

Roland, Michelle ;

Page-Shafer, Kimberly ;

Hsue, Priscilla ;

Emu, Brinda ;

Krone, Melissa ;

Lampiris, Harry ;

Douek, Daniel ;

Martin, Jeffrey N. ;

Deeks, Steven G. .

JOURNAL OF INFECTIOUS DISEASES, 2008, 197 (01) :126-133

← 1 2 →