Polysaccharide-rich fraction of Termitomyces eurhizus accelerate healing of indomethacin induced gastric ulcer in mice

被引：50

作者：

Chatterjee, Ananya ^{[1
,2
,3
]}

Khatua, Somanjana ^{[3
]}

Chatterjee, Sirshendu ^{[1
]}

Mukherjee, Shatavisa ^{[1
]}

Mukherjee, Atashi ^{[1
]}

Paloi, Soumitra ^{[3
]}

Acharya, Krishnendu ^{[3
]}

Bandyopadhyay, Sandip K. ^{[1
,2
]}

机构：

[1] KPC Med Coll & Hosp, Dept Biochem, Cent Res Lab, Kolkata 700032, W Bengal, India

[2] Univ Coll Med, IPGM E&R, Dept Biochem, Res Wing, Kolkata 700020, W Bengal, India

[3] Univ Calcutta, Dept Bot, Mol & Appl Mycol & Plant Pathol Lab, Kolkata 700019, W Bengal, India

来源：

GLYCOCONJUGATE JOURNAL | 2013年 / 30卷 / 08期

关键词：

Gastric ulcer; Mushroom; NSAIDs; Polysaccharide; Termitomyces eurhizus; NITRIC-OXIDE SYNTHASE; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; MUCOSAL INJURY; INTESTINAL INFLAMMATION; MEDICINAL MUSHROOMS; GANODERMA-LUCIDUM; MECHANISM; CYCLOOXYGENASE-2; MYELOPEROXIDASE; GROWTH;

D O I：

10.1007/s10719-013-9479-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The current study aims to determine the healing activity of water soluble polysaccharide-rich fraction of a wild mushroom, Termitomyces eurhizus (TEps) against the indomethacin induced gastric ulceration in mice model. Gastric tissue histology, myeloperoxidase (MPO) activity, cyclooxygenases (COX) 1 and 2 expression, prostaglandin E-2 (PGE(2)) synthesis, and modulation of pro/anti inflammatory cytokines expression were studied for this purpose. Histological study shows that TEps (20 mg/kg) effectively healed the gastric ulceration. Based on biochemical results, the healing capacities of TEps could be attributed to reduction of MPO activity and protection of mucosal mucin content. Enhanced synthesis of PGE(2) by modulation of COX-1 and COX-2 expression and a prominent shift of cytokines expression from pro (TNF-alpha, IL-1) to anti inflammatory (IL-10) side are also held responsible for ulcer healing. The preliminary study highlights the anti-ulcerogenic property of polysaccharide-rich fraction of Termitomyces eurhizus and opens an alternative cure for NSAID induced gastroduodenal diseases.

引用

页码：759 / 768

页数：10

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