Presence of pili on the surface of Francisella tularensis

被引：57

作者：

Gil, H ^{[1
]}

Benach, JL ^{[1
]}

Thanassi, DG ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Mol Genet & Microbiol, Ctr Infect Dis, Stony Brook, NY 11794 USA

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 05期

关键词：

D O I：

10.1128/IAI.72.5.3042-3047.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Francisella tularensis is a highly infectious gram-negative bacterium with potential for use as a bioweapon. Analysis of the F. tularensis live vaccine strain (LVS) ultrastructure by electron microscopy revealed the presence of long, thin fibers, similar in appearance to type 4 pili. The highly virulent F. tularensis Schu S4 strain was found to contain type 4 pilus genes, and we confirmed that these genes are present and expressed in the LVS.

引用

页码：3042 / 3047

页数：6

共 33 条

[1] IDENTIFICATION OF A GENE, PILV, REQUIRED FOR TYPE-4 FIMBRIAL BIOGENESIS IN PSEUDOMONAS-AERUGINOSA, WHOSE PRODUCT POSSESSES A PRE-PILIN-LIKE LEADER SEQUENCE [J].

ALM, RA ;

MATTICK, JS .

MOLECULAR MICROBIOLOGY, 1995, 16 (03) :485-496

[2] MgIA and MgIB are required for the intramacrophage growth of Francisella novicida [J].

Baron, GS ;

Nano, FE .

MOLECULAR MICROBIOLOGY, 1998, 29 (01) :247-259

[3] EVALUATION OF LIVE TULAREMIA VACCINE PREPARED IN A CHEMICALLY DEFINED MEDIUM [J].

CHAMBERL.RE .

APPLIED MICROBIOLOGY, 1965, 13 (02) :232-&

[4] INCREASED ENCAPSULATION AND VIRULENCE OF FRANCISELLA-TULARENSIS LIVE VACCINE STRAIN (LVS) BY SUBCULTURING ON SYNTHETIC MEDIUM [J].

CHERWONOGRODZKY, JW ;

KNODEL, MH ;

SPENCE, MR .

VACCINE, 1994, 12 (09) :773-775

[5] Three-dimensional structure of the Neisseria meningitidis secretin PilQ determined from negative-stain transmission electron microscopy [J].

Collins, RF ;

Ford, RC ;

Kitmitto, A ;

Olsen, RO ;

Tonjum, T ;

Derrick, JP .

JOURNAL OF BACTERIOLOGY, 2003, 185 (08) :2611-2617

[6] Pseudomonas aeruginosa gene products PilT and PilU are required for cytotoxicity in vitro and virulence in a mouse model of acute pneumonia [J].

Comolli, JC ;

Hauser, AR ;

Waite, L ;

Whitchurch, CB ;

Mattick, JS ;

Engel, JN .

INFECTION AND IMMUNITY, 1999, 67 (07) :3625-3630

[7] Tularemia as a biological weapon - Medical and public health management [J].

Dennis, DT ;

Inglesby, TV ;

Henderson, DA ;

Bartlett, JG ;

Ascher, MS ;

Eitzen, E ;

Fine, AD ;

Friedlander, AM ;

Hauer, J ;

Layton, M ;

Lillibridge, SR ;

McDade, JE ;

Osterholm, MT ;

O'Toole, T ;

Parker, G ;

Perl, TM ;

Russell, PK ;

Tonat, K .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (21) :2763-2773

[8] Tularemia on Martha's vineyard: Seroprevalence and occupational risk [J].

Feldman, KA ;

Stiles-Enos, D ;

Julian, K ;

Matyas, BT ;

Telford, SR ;

Chu, MC ;

Petersen, LR ;

Hayes, EB .

EMERGING INFECTIOUS DISEASES, 2003, 9 (03) :350-354

[9] Francisella tularensis selectively induces proinflammatory changes in endothelial cells [J].

Forestal, CA ;

Benach, JL ;

Carbonara, C ;

Italo, JK ;

Lisinski, TJ ;

Furie, MB .

JOURNAL OF IMMUNOLOGY, 2003, 171 (05) :2563-2570

[10] Molecular analyses of the natural transformation machinery and identification of pilus structures in the extremely thermophilic bacterium Thermus thermophilus strain HB27 [J].

Friedrich, A ;

Prust, C ;

Hartsch, T ;

Henne, A ;

Averhoff, B .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2002, 68 (02) :745-755

← 1 2 3 4 →