Heterochromatin maintenance and establishment Lessons from the mouse pericentromere

被引：73

作者：

Almouzni, Genevieve ^{[1
,2
]}

Probst, Aline V. ^{[3
]}

机构：

[1] Inst Curie, Ctr Rech, Paris, France

[2] CNRS, UMR218, Paris, France

[3] Clermont Univ, GReD, INSERM U931, CNRS UMR 6247, Aubiere, France

来源：

NUCLEUS | 2011年 / 2卷 / 05期

关键词：

heterochromatin; non-coding RNA; development; chromatin; pericentromere; H3; LYSINE-9; METHYLATION; GAMMA-SATELLITE DNA; CONSTITUTIVE HETEROCHROMATIN; EPIGENETIC INHERITANCE; HISTONE MODIFICATION; S-PHASE; CHROMATIN; RNA; TRANSCRIPTION; VARIANTS;

D O I：

10.4161/nucl.2.5.17707

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Defined as a chromatin structure that remains condensed throughout the cell cycle heterochromatin is generally transcriptionally silent and is characterized by a specific molecular signature. Constitutive heterochromatin at the pericentromere is a conserved feature throughout evolution, which impacts genome stability. Here, we will summarize recent advances in our understanding of the dynamics of mouse pericentric heterochromatin during the cell cycle and development. Comparison with heterochromatin maintenance in fission yeast will enable discussions of the common basic principles and various mechanisms exploited in the distinct organisms.

引用

页码：332 / 338

页数：7

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