Cyclin B1 and other cyclins as tumor antigens in immunosurveillance and immunotherapy of cancer

被引：82

作者：

Egloff, AM

Vella, LA

Finn, OJ

机构：

[1] Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Inst Canc, Pittsburgh, PA 15261 USA

来源：

CANCER RESEARCH | 2006年 / 66卷 / 01期

关键词：

D O I：

10.1158/0008-5472.CAN-05-3389

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Uncontrolled cell division is an indispensable event in tumor progression, and numerous molecules involved in this process have been the focus of intense investigation in tumor biology. Cyclins, molecules that orchestrate normal cell cycle progression, are abnormally overexpressed in various human cancers. We review evidence that the immune system recognizes some abnormally expressed cyclins as tumor antigens, such as cyclin B1, and we analyze the potential of cyclins D, E, and A to serve a similar function in cancer immunosurveillance.

引用

页码：6 / 9

页数：4

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