Asymmetric synthesis of the C3α fragment of 5,6-dihydro-α-pyrone nonpeptidic HIV-1 protease inhibitors

被引：21

作者：

Romero, DL ^{[1
]}

Manninen, PR ^{[1
]}

Han, FS ^{[1
]}

Romero, AG ^{[1
]}

机构：

[1] Pharmacia & Upjohn Inc, Med Chem Res & Struct, Analyt & Med Chem, Kalamazoo, MI 49001 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 13期

关键词：

D O I：

10.1021/jo990278d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[No abstract available]

引用

页码：4980 / 4984

页数：5

共 21 条

[1] THE 3-D STRUCTURE OF HIV-1 PROTEINASE AND THE DESIGN OF ANTIVIRAL AGENTS FOR THE TREATMENT OF AIDS [J].

BLUNDELL, TL ;

LAPATTO, R ;

WILDERSPIN, AF ;

HEMMINGS, AM ;

HOBART, PM ;

DANLEY, DE ;

WHITTLE, PJ .

TRENDS IN BIOCHEMICAL SCIENCES, 1990, 15 (11) :425-430

[2] A convergent, scalable synthesis of HIV protease inhibitor PNU-140690 [J].

Fors, KS ;

Gage, JR ;

Heier, RF ;

Kelly, RC ;

Perrault, WR ;

Wicnienski, N .

JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (21) :7348-7356

[3]

HUCKIN SN, 1971, TETRAHEDRON LETT, V50, P4835

[4] Asymmetric syntheses and absolute stereochemistry of 5,6-dihydro-alpha-pyrones, a new class of potent HIV protease inhibitors [J].

Judge, TM ;

Phillips, G ;

Morris, JK ;

Lovasz, KD ;

Romines, KR ;

Luke, GP ;

Tulinsky, J ;

Tustin, JM ;

Chrusciel, RA ;

Dolak, LA ;

Mizsak, SA ;

Watt, W ;

Morris, J ;

VanderVelde, SL ;

Strohbach, JW ;

Gammill, RB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (15) :3627-3628

[5]

Kempf DJ, 1996, CURR PHARM DESIGN, V2, P225

[6] PRACTICAL SYNTHESIS OF BINAP-RUTHENIUM(II) DICARBOXYLATE COMPLEXES [J].

KITAMURA, M ;

TOKUNAGA, M ;

NOYORI, R .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (14) :4053-4054

[7] A NOVEL STEREOSPECIFIC HYDROHALOGENATION REACTION OF PROPIOLATES AND PROPIOLIC ACID [J].

MA, SM ;

LU, XY .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1990, (22) :1643-1644

[8] A HIGHLY EFFICIENT SYNTHESIS OF (Z) GAMMA-IODO ALLYLIC ALCOHOLS [J].

MAREK, I ;

ALEXAKIS, A ;

NORMANT, JF .

TETRAHEDRON LETTERS, 1991, 32 (39) :5329-5332

[9] SYNTHESIS OF NEW CATIONIC BINAP-RUTHENIUM(II) COMPLEXES AND THEIR USE IN ASYMMETRIC HYDROGENATION [BINAP = 2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHYL] [J].

MASHIMA, K ;

KUSANO, KH ;

OHTA, T ;

NOYORI, R ;

TAKAYA, H .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (17) :1208-1210

[10]

NOYORI R, 1994, ASYMMETRIC CATALYSIS, P32

← 1 2 3 →