Tumour escape from immune surveillance through dendritic cell inactivation

被引：197

作者：

Vicari, AP ^{[1
]}

Caux, C ^{[1
]}

Trinchieri, G ^{[1
]}

机构：

[1] Schering Plough Res Inst, Lab Immunol Res, F-69571 Dardilly, France

来源：

SEMINARS IN CANCER BIOLOGY | 2002年 / 12卷 / 01期

关键词：

tumour escape; dendritic cells; chemokines; tumour antigen presentation; antigen presenting cells;

D O I：

10.1006/scbi.2001.0400

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dendritic cells (DC) are central to the initiation of immunity. To induce immune reactivity, DC are recruited at the site of antigen expression, uptake antigens and migrate to secondary lymphoid organs while receiving activation signals delivered by pathogens, dying cells, and/or T cells. Tumours can escape the immune system by interfering with the migration of DC or by not providing the necessary activation signals. Moreover, tumours promote the secretion of factors that inhibit DC differentiation and functions. We will review the current knowledge of the physiopathology of DC in cancer, which paves the way for novel strategies of therapeutic intervention.

引用

页码：33 / 42

页数：10

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