Resolution of Inflammation in Asthma

被引：52

作者：

Levy, Bruce D. ^{[1
,2
]}

Vachier, Isabelle ^{[3
]}

Serhan, Charles N. ^{[2
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Harvard Inst Med, Med Sch,Dept Internal Med, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Ctr Expt Therapeut & Reperfus Injury, Dept Anesthesiol Perioperat & Pain Med, Boston, MA 02115 USA

[3] CHRU Montpellier, Arnaud de Villeneuve Hosp, Dept Resp Dis, F-34295 Montpellier, France

来源：

CLINICS IN CHEST MEDICINE | 2012年 / 33卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Inflammation; Resolution; Lipoxins; Mediators; Asthma; ASPIRIN-TRIGGERED 15-EPI-LXA(4); DAMPENS AIRWAY INFLAMMATION; LIPOXIN A(4) RECEPTORS; N-3; FATTY-ACIDS; LEUKOTRIENE B-4; RESOLVIN E1; TRANSGENIC MICE; LIPID MEDIATORS; ANTIINFLAMMATORY ACTIONS; APOPTOTIC NEUTROPHILS;

D O I：

10.1016/j.ccm.2012.06.006

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The resolution of inflammation in healthy airways is an active process, with specialized mediators and cellular mechanisms enlisted to restore tissue homeostasis. This article focuses on recent discoveries of natural mediators derived from essential fatty acids, including omega-3 fatty acids, with anti-inflammatory and pro-resolving. These pro-resolving mediators serve as agonists at specific receptors. Asthma is an incurable disease of chronic, nonresolving inflammation of the airways. While the biosynthesis of pro-resolving mediators occurs during asthma, defects in their production are associated with disease severity, suggesting that the pathobiology of asthma may result in part from impaired resolution of airway inflammation.

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收藏

页码：559 / +

页数：13

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