Dcp1a phosphorylation along neuronal development and stress

被引：17

作者：

Blumenthal, Jacob ^{[1
]}

Behar, Leah ^{[1
]}

Elliott, Evan ^{[1
]}

Ginzburg, Irith ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel

来源：

FEBS LETTERS | 2009年 / 583卷 / 01期

基金：

以色列科学基金会;

关键词：

Dcp1a; P-bodies; Stress granules; Arsenate; Neuronal development; MESSENGER-RNA TURNOVER; SACCHAROMYCES-CEREVISIAE; DECAPPING ENZYME; CELLS; PROTEIN; YEAST; EXOSOME; SITES; DECAY;

D O I：

10.1016/j.febslet.2008.12.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Decapping protein 1a (Dcp1a) is found in P-bodies and functions in mRNA cap removal prior to its degradation. The function and binding partners of Dcp1a have been thoroughly studied, however its expression pattern is still unclear. In this study we have monitored Dcp1a expression along brain development, neuronal differentiation and during cellular stress. We found that Dcp1a is hyper-phosphorylated under these physiological conditions. We followed our observations and identified the specific amino acid residues that are phosphorylated. These findings suggest a novel post-translational modi. cation that may influence the function of Dcp1a in response to various physiological cues. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：197 / 201

页数：5

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