Plasmalogen-selective phospholipase A(2) and its role in signal transduction

被引：45

作者：

Yang, HC ^{[1
]}

Farooqui, AA ^{[1
]}

Horrocks, LA ^{[1
]}

机构：

[1] OHIO STATE UNIV, DEPT MED BIOCHEM, COLUMBUS, OH 43210 USA

来源：

JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING | 1996年 / 14卷 / 1-3期

关键词：

arachidonic acid; gangliosides; glycoconjugates; glycosaminoglycans; phospholipases A(2); plasmalogen; signal transduction;

D O I：

10.1016/0929-7855(96)01502-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The breakdown of plasmalogens in neural membranes is a receptor-mediated process catalyzed by a plasmalogen-selective phospholipase A(2). This enzyme has been isolated from bovine brain. It is localized in cytosol and does not require Ca2+ for its activity. It has a molecular weight of 39 kDa and is strongly inhibited by glycosaminoglycans, gangliosides and sialoglycoproteins. The interactions between plasmalogen-selective phospholipase A(2) and glycoconjugates may be involved in the regulation of enzymic activity. Under normal conditions, plasmalogen-selective phospholipase A(2) provides second messengers such as arachidonic acid and eicosanoids. However, under pathological conditions, this enzyme may be involved in a massive release of free fatty acids that may cause serious cell and tissue damage.

引用

页码：9 / 13

页数：5

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