Solvent- and Catalyst-Free Huisgen Cycloaddition to Rufinamide in Flow with a Greener, Less Expensive Dipolarophile

被引：48

作者：

Borukhova, Svetlana ^{[1
]}

Noel, Timothy ^{[1
]}

Metten, Bert ^{[2
]}

de Vos, Eric ^{[2
]}

Hessel, Volker ^{[1
]}

机构：

[1] Eindhoven Univ Technol, Dept Chem Engn & Chem Micro Flow Chem & Proc Tech, NL-5612 AZ Eindhoven, Netherlands

[2] SA Ajinomoto OmniChem NV, B-9230 Wetteren, Belgium

来源：

CHEMSUSCHEM | 2013年 / 6卷 / 12期

基金：

欧洲研究理事会;

关键词：

cycloaddition; green chemistry; microflow chemistry; novel process windows; solvent free; PROCESS DESIGN; PROCESS WINDOWS; DRUG DISCOVERY; COST-ANALYSIS; CHEMISTRY; MICROREACTOR;

D O I：

10.1002/cssc.201300684

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Give it a flow: A continuous-flow process for the synthesis of a 1,2,3-triazole precursor of Rufinamide has been developed. The protocol involves a solvent- and catalyst-free operation and utilizes reaction temperatures above the melting point of the target product to prevent microreactor clogging, resulting in a decrease of the operating time from hours to minutes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2220 / 2225

页数：6

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