Pathogenesis of pterygia: role of cytokines, growth factors, and matrix metalloproteinases

被引：278

作者：

Di Girolamo, N ^{[1
]}

Chui, J

Coroneo, MT

Wakefield, D

机构：

[1] Univ New S Wales, Sch Med Sci, Dept Pathol, Inflammatory Dis Res Unt, Sydney, NSW 2052, Australia

[2] Prince Wales Hosp, Dept Ophthalmol, Sydney, NSW 2052, Australia

来源：

PROGRESS IN RETINAL AND EYE RESEARCH | 2004年 / 23卷 / 02期

关键词：

D O I：

10.1016/j.preteyeres.2004.02.002

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Pterygium is a common ocular surface disease apparently only observed in humans. Chronic UV exposure is a widely accepted aetiological factor in the pathogenesis of this disease and this concept is supported by epidemiological data, ray tracing models and histopathological changes that share common features with UV damaged skin. The mechanism(s) of pterygium formation is incompletely understood. Recent data have provided evidence implicating a genetic component, anti-apoptotic mechanisms, cytokines, growth factors, extracellular matrix remodelling (through the actions of matrix metalloproteinases), immunological mechanisms and viral infections in the pathogenesis of this disease. In this review, the current knowledge on pterygium pathogenesis is summarised, highlighting recent developments. In addition, we provide novel data further demonstrating the complexity of this intriging disease. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：195 / 228

页数：34

共 336 条

[1] Intercellular communication between vascular smooth muscle and endothelial cells mediated by heparin-binding epidermal growth factor-like growth factor and vascular endothelial growth factor [J].