Engineering of Hetero-Functional Gold Nanorods for the in vivo Molecular Targeting of Breast Cancer Cells

被引：191

作者：

Eghtedari, Mohammad ^{[1
]}

Liopo, Anton V. ^{[1
]}

Copland, John A. ^{[2
]}

Oraevslty, Alexander A. ^{[3
]}

Motamedi, Massoud ^{[1
]}

机构：

[1] Univ Texas Med Branch Galveston, Ctr Biomed Engn, Galveston, TX 77555 USA

[2] Mayo Clin, Ctr Comprehens Canc, Dept Canc Biol, Jacksonville, FL 32224 USA

[3] Fairway Med Technol, Houston, TX 77099 USA

来源：

NANO LETTERS | 2009年 / 9卷 / 01期

基金：

美国国家科学基金会;

关键词：

COLLOIDAL GOLD; CONTRAST AGENT; PHOTOTHERMAL THERAPY; NANOPARTICLES; SURFACE; TOMOGRAPHY; NANOTECHNOLOGY; AGGREGATION; SENSITIVITY; DIAGNOSTICS;

D O I：

10.1021/nl802915q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel technique is described to functionalize gold nanorods (GNRs) allowing for in vivo targeting of breast cancer tumors grown in athymic nude mice. GNRs were functionalized by covalent attachment of Herceptin (HER), a monoclonal antibody that enables molecular recognition of breast cancer cells expressing highly specific tumor associated antigens, and poly(ethylene glycol) (PEG) which obscures particles against the reticuloendothelial system in the body. The stability and functionality of fabricated particles (Her-PEG GNRs) were demonstrated in vitro in the presence of blood and then in vivo in nude mice model for breast cancer. The results demonstrate successful tumor accumulation of functionalized gold nanorods within HER2/neu overexpressing breast tumors in tumor-bearing nude mice and support the notions that GNRs can be used for molecular imaging of tumor.

引用

页码：287 / 291

页数：5

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