Multidrug Resistance Mediated by MRP1 Gene Overexpression in Breast Cancer Patients

被引：25

作者：

Abaan, Ogan Demir ^{[1
,2
]}

Mutlu, Pelin Kaya ^{[1
]}

Baran, Yusuf ^{[1
,3
]}

Atalay, Can ^{[1
,4
]}

Gunduz, Ufuk ^{[1
]}

机构：

[1] Middle E Tech Univ, Dept Biol, TR-06531 Ankara, Turkey

[2] Georgetown Univ, Dept Oncol, Lombardi Comphrenes Canc Ctr, Washington, DC USA

[3] Izmir Inst Technol, Dept Mol Biol & Genet, Izmir, Turkey

[4] Ankara Oncol Hosp, Dept Gen Surg, Ankara, Turkey

来源：

CANCER INVESTIGATION | 2009年 / 27卷 / 02期

关键词：

Multidrug resistance; MDR; MRP1; Breast cancer; Chemotherapy; MRP Family; HUMAN TUMOR-CELLS; LEUKEMIA-CELLS; PROTEIN MRP; DRUG-RESISTANCE; EXPRESSION; CARCINOMA; MDR1;

D O I：

10.1080/07357900802173562

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Multidrug resistance (MDR) is a serious handicap towards the effective treatment of breast cancer patients. One of the most prevalent MDR mechanisms is through the overexpression of genes coding the proteins called Multidrug Resistance-associated Proteins (MRPs). The aim of this study was to investigate the expression of MRP1 in tumor tissues from breast cancer patients. In this study, a semi-quantitative RT-PCR approach was utilized. Our results suggest that MRP1 overexpression can mediate MDR in patients. Pre-evaluation of the level of such MDR mediators before chemotherapy can increase the efficacy of the treatment.

引用

页码：201 / 205

页数：5

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