The Arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor I kappa B

被引：391

作者：

Ryals, J ^{[1
]}

Weymann, K ^{[1
]}

Lawton, K ^{[1
]}

Friedrich, L ^{[1
]}

Ellis, D ^{[1
]}

Steiner, HY ^{[1
]}

Johnson, J ^{[1
]}

Delaney, TP ^{[1
]}

Jesse, T ^{[1
]}

Vos, P ^{[1
]}

Uknes, S ^{[1
]}

机构：

[1] KEYGENE NV, NL-6700 AE WAGENINGEN, NETHERLANDS

来源：

PLANT CELL | 1997年 / 9卷 / 03期

关键词：

D O I：

10.1105/tpc.9.3.425

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The NIM1 (for noninducible immunity) gene product is involved in the signal transduction cascade leading to both systemic acquired resistance (SAR) and gene-for-gene disease resistance in Arabidopsis. We have isolated and characterized five new alleles of nim1 that show a range of phenotypes from weakly impaired in chemically induced pathogenesis-related protein-1 gene expression and fungal resistance to very strongly blocked. We have isolated the NIM1 gene by using a map-based cloning procedure. Interestingly, the NIM1 protein shows sequence homology to the mammalian signal transduction factor I kappa B subclass alpha. NF-kappa B/I kappa B signaling pathways are implicated in disease resistance responses in a range of organisms from Drosophila to mammals, suggesting that the SAR signaling pathway in plants is representative of an ancient and ubiquitous defense mechanism in higher organisms.

引用

页码：425 / 439

页数：15

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