Decreased Kruppel-like factor 4 (KLF4) expression may correlate with poor survival in gastric adenocarcinoma

被引：35

作者：

Hsu, Li-Sung ^{[1
,2
]}

Chan, Chien-Pin ^{[3
]}

Chen, Chih-Jung ^{[4
,5
]}

Lin, Shu-Hui ^{[4
,5
]}

Lai, Ming-Tsung ^{[6
,7
]}

Hsu, Jeng-Dong ^{[6
,7
]}

Yeh, Kun-Tu ^{[4
,6
]}

Soon, Maw-Soan ^{[8
,9
,10
]}

机构：

[1] Chung Shan Med Univ, Inst Biochem & Biotechnol, Taichung, Taiwan

[2] Chung Shan Med Univ Hosp, Clin Lab, Taichung, Taiwan

[3] Changhua Christian Hosp, Dept Gen Surg, Changhua, Taiwan

[4] Changhua Christian Hosp, Dept Pathol, Changhua, Taiwan

[5] Jen Teh Jr Coll Med Nursing & Management, Dept Med Technol, Miaoli, Taiwan

[6] Chung Shan Med Univ, Sch Med, Dept Pathol, Taichung, Taiwan

[7] Chung Shan Med Univ Hosp, Dept Pathol, Taichung, Taiwan

[8] Changhua Christian Hosp, Dept Gastroenterol, Changhua, Taiwan

[9] Natl Changhua Univ Educ, Grad Inst Biotechnol, Changhua, Taiwan

[10] Chien Kuo Technol Univ, Gen Educ Ctr, Changhua, Taiwan

来源：

MEDICAL ONCOLOGY | 2013年 / 30卷 / 04期

关键词：

Kruppel-like factor 4; Gastric adenocarcinoma; Immunohistochemical stain; TRANSCRIPTION FACTORS; TUMOR-SUPPRESSOR; DOWN-REGULATION; CANCER DEVELOPMENT; CELL-GROWTH; PROGRESSION; SP1; KRUPPEL-LIKE-FACTOR-4; DIFFERENTIATION; PROLIFERATION;

D O I：

10.1007/s12032-013-0632-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Kruppel-like factors (KLFs) play either anti-or pro-proliferation roles in different human cancers. Here, we investigated the expression of KLF4 in gastric cancers and its correlation with clinicopathological parameters and overall survival. KLF4 expression was measured in 118 surgical specimens by immunohistochemical microarray assay. No association of cytoplasmic KLF4 expression with gender, TNM status, stage, survival, and pathological type was found. Using Kaplan-Meier analysis, significantly higher overall survival rate was observed in patients with high cytoplasmic KLF4 expression compared to low cytoplasmic KLF4 expression. Univariate analysis revealed that cytoplasmic KLF4 expression, grade, histological type, lymph node metastasis, and stages were correlated to longer overall survival. Our results suggest that KLF4 may play an anti-oncogenic role in gastric tumorigenesis.

引用

页数：6

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