A Conserved Dedicated Olfactory Circuit for Detecting Harmful Microbes in Drosophila

被引：451

作者：

Stensmyr, Marcus C. ^{[1
]}

Dweck, Hany K. M. ^{[1
]}

Farhan, Abu ^{[1
]}

Ibba, Irene ^{[1
]}

Strutz, Antonia ^{[1
]}

Mukunda, Latha ^{[1
]}

Linz, Jeanine ^{[1
]}

Grabe, Veit ^{[1
]}

Steck, Kathrin ^{[1
]}

Lavista-Llanos, Sofia ^{[1
]}

Wicher, Dieter ^{[1
]}

Sachse, Silke ^{[1
]}

Knaden, Markus ^{[1
]}

Becher, Paul G. ^{[2
]}

Seki, Yoichi ^{[1
]}

Hansson, Bill S. ^{[1
]}

机构：

[1] Max Planck Inst Chem Ecol, Dept Evolutionary Neuroethol, D-07745 Jena, Germany

[2] Swedish Univ Agr Sci, Div Chem Ecol, S-23053 Alnarp, Sweden

来源：

CELL | 2012年 / 151卷 / 06期

基金：

瑞典研究理事会;

关键词：

ANTENNAL LOBE; SENSORY INPUT; NEURONS; GEOSMIN; PHEROMONE; BEHAVIOR; SYSTEM; REPRESENTATIONS; INTERNEURONS; ORGANIZATION;

D O I：

10.1016/j.cell.2012.09.046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Flies, like all animals, need to find suitable and safe food. Because the principal food source for Drosophila melanogaster is yeast growing on fermenting fruit, flies need to distinguish fruit with safe yeast from yeast covered with toxic microbes. We identify a functionally segregated olfactory circuit in flies that is activated exclusively by geosmin. This microbial odorant constitutes an ecologically relevant stimulus that alerts flies to the presence of harmful microbes. Geosmin activates only a single class of sensory neurons expressing the olfactory receptor Or56a. These neurons target the DA2 glomerulus and connect to projection neurons that respond exclusively to geosmin. Activation of DA2 is sufficient and necessary for aversion, overrides input from other olfactory pathways, and inhibits positive chemotaxis, oviposition, and feeding. The geosmin detection system is a conserved feature in the genus Drosophila that provides flies with a sensitive, specific means of identifying unsuitable feeding and breeding sites.

引用

页码：1345 / 1357

页数：13

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