From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines

被引：337

作者：

Banchereau, Jacques ^{[1
]}

Pascual, Virginia ^{[1
]}

O'Garra, Anne ^{[2
]}

机构：

[1] Baylor Inst Immunol Res, Dallas, TX USA

[2] MRC Natl Inst Med Res, Div Immunoregulat, London, England

来源：

NATURE IMMUNOLOGY | 2012年 / 13卷 / 10期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

REGULATORY T-CELLS; GROWTH-FACTOR-BETA; IMMUNOLOGICAL SELF-TOLERANCE; LATENT TGF-BETA; DENDRITIC CELLS; IN-VIVO; INTERLEUKIN-2; DEFICIENT; IMMUNE DYSREGULATION; EXPRESSION; INDUCTION;

D O I：

10.1038/ni.2406

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Feedback regulatory circuits provided by regulatory T cells (T-reg cells) and suppressive cytokines are an intrinsic part of the immune system, along with effector functions. Here we discuss some of the regulatory cytokines that have evolved to permit tolerance to components of self as well as the eradication of pathogens with minimal collateral damage to the host. Interleukin 2 (IL-2), IL-10 and transforming growth factor-beta (TGF-beta) are well characterized, whereas IL-27, IL-35 and IL-37 represent newcomers to the spectrum of anti-inflammatory cytokines. We also emphasize how information accumulated through in vitro as well as in vivo studies of genetically engineered mice can help in the understanding and treatment of human diseases.

引用

收藏

页码：925 / 931

页数：7

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