Glycoproteins: glycan presentation and protein-fold stability

被引：229

作者：

Wormald, MR ^{[1
]}

Dwek, RA ^{[1
]}

机构：

[1] Univ Oxford, Dept Biochem, Oxford Glycobiol Inst, Oxford OX1 3QU, England

来源：

STRUCTURE | 1999年 / 7卷 / 07期

关键词：

D O I：

10.1016/S0969-2126(99)80095-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycosylation of proteins has been shown to play a role in a variety of cellular events. Thanks to recent advances in obtaining conformational constraints across glycosidic linkages, structural characterisation of glycoproteins has improved considerably. It is now becoming apparent that N-glycosylation of a folded protein can have a significant stabilising effect on large regions of the backbone structure.

引用

页码：R155 / R160

页数：6

共 35 条

[1] CRYSTAL-STRUCTURE OF THE EXTRACELLULAR REGION OF THE HUMAN CELL-ADHESION MOLECULE CD2 AT 2.5-ANGSTROM RESOLUTION [J].

BODIAN, DL ;

JONES, EY ;

HARLOS, K ;

STUART, DI ;

DAVIS, SJ .

STRUCTURE, 1994, 2 (08) :755-766

[2] T-cell activation: Interplay at the interface [J].

Brown, MJ ;

Shaw, S .

CURRENT BIOLOGY, 1999, 9 (01) :R26-+

[3] Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction [J].

Corper, AL ;

Sohi, MK ;

Bonagura, VR ;

Steinitz, M ;

Jefferis, R ;

Feinstein, A ;

Beale, D ;

Taussig, MJ ;

Sutton, BJ .

NATURE STRUCTURAL BIOLOGY, 1997, 4 (05) :374-381

[4]

DAVIS JT, 1994, J BIOL CHEM, V269, P3331

[5]

DeBeer T, 1996, EUR J BIOCHEM, V241, P229

[6] CRYSTALLOGRAPHIC STRUCTURAL STUDIES OF A HUMAN FC FRAGMENT .2. COMPLETE MODEL BASED ON A FOURIER MAP AT 3.5 A RESOLUTION [J].

DEISENHOFER, J ;

COLMAN, PM ;

EPP, O ;

HUBER, R .

HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1976, 357 (10) :1421-1434

[7] CRYSTALLOGRAPHIC REFINEMENT AND ATOMIC MODELS OF A HUMAN FC FRAGMENT AND ITS COMPLEX WITH FRAGMENT-B OF PROTEIN-A FROM STAPHYLOCOCCUS-AUREUS AT 2.9-A AND 2.8-A RESOLUTION [J].

DEISENHOFER, J .

BIOCHEMISTRY, 1981, 20 (09) :2361-2370

[8] STRUCTURE OF DOMAIN-1 OF RAT LYMPHOCYTE-T CD2 ANTIGEN [J].

DRISCOLL, PC ;

CYSTER, JG ;

CAMPBELL, ID ;

WILLIAMS, AF .

NATURE, 1991, 353 (6346) :762-765

[9] EFFECTS OF GLYCOSYLATION ON THE CONFORMATION AND DYNAMICS OF O-LINKED GLYCOPROTEINS - C-13 NMR-STUDIES OF OVINE SUBMAXILLARY MUCIN [J].

GERKEN, TA ;

BUTENHOF, KJ ;

SHOGREN, R .

BIOCHEMISTRY, 1989, 28 (13) :5536-5543

[10] Glycosylation affects both the three-dimensional structure and antibody binding properties of the HIV-1(IIIB) GP120 peptide RP135 [J].

Huang, XL ;

Barchi, JJ ;

Lung, EDT ;

Roller, PP ;

Nara, PL ;

Muschik, J ;

Garrity, RR .

BIOCHEMISTRY, 1997, 36 (36) :10846-10856

← 1 2 3 4 →