Clinical and MRI Outcomes After Platelet-Rich Plasma Treatment for Knee Osteoarthritis

被引：114

作者：

Halpern, Brian ^{[1
]}

Chaudhury, Salma ^{[1
]}

Rodeo, Scott A. ^{[1
]}

Hayter, Catherine ^{[1
]}

Bogner, Eric ^{[1
]}

Potter, Hollis G. ^{[1
]}

Nguyen, Joseph ^{[1
]}

机构：

[1] Hosp Special Surg, New York, NY 10021 USA

来源：

CLINICAL JOURNAL OF SPORT MEDICINE | 2013年 / 23卷 / 03期

关键词：

knee; osteoarthritis; platelet-rich plasma; magnetic resonance imaging (MRI);

D O I：

10.1097/JSM.0b013e31827c3846

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

The purpose of this study was to investigate whether platelet-rich plasma therapy for early knee osteoarthritis is associated with good clinical outcomes and a change in magnetic resonance imaging (MRI) structural appearances. The design was a prospective cohort study following patients 1 year after platelet-rich plasma therapy for knee osteoarthritis. Twenty-two patients were treated with platelet-rich plasma for early osteoarthritis, confirmed with a baseline MRI. Inclusion criteria were Kellgren grade 0-II with knee pain in patients aged 30 to 70 years. All the patients received a 6-mL platelet-rich plasma injection using the Cascade system. Fifteen subjects underwent clinical assessments at baseline, 1 week, and 1, 3, 6, and 12 months, and MRIs at 1 year. Pain scores significantly decreased, whereas functional and clinical scores increased at 6 months and 1 year from baseline. Qualitative MRIs demonstrated no change per compartment in at least 73% of cases at 1 year.

引用

页码：238 / 239

页数：2

共 7 条

[1]

Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients [J].