Antiviral properties of isoborneol, a potent inhibitor of herpes simplex virus type 1

被引：111

作者：

Armaka, M ^{[1
]}

Papanikolaou, E ^{[1
]}

Sivropoulou, A ^{[1
]}

Arsenakis, M ^{[1
]}

机构：

[1] Aristotelian Univ Salonika, Lab Gen Microbiol, Sect Genet Dev & Mol Biol, Sch Biol, GR-54006 Salonika, Greece

来源：

ANTIVIRAL RESEARCH | 1999年 / 43卷 / 02期

关键词：

anti-herpes simplex virus agents; antiviral agents; borneol; essential oil; glycoproteins of HSV-1; glycosylation; glycosylation inhibitors; herpes simplex virus 1; HSV-1; isoborneol; monoterpenes; Salvia fruticosa; specific inhibitors of viral glycosylation; transformed Vero cells;

D O I：

10.1016/S0166-3542(99)00036-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Isoborneol, a monoterpene and a component of several plant essential oils, showed dual viricidal activity against herpes simplex virus 1 (HSV-1). First, it inactivated HSV-1 by almost 4 log(10) values within 30 min of exposure, and second, isoborneol at a concentration of 0.06% completely inhibited viral replication, without affecting viral adsorption. Isoborneol did not exhibit significant cytotoxicity at concentrations ranging between 0.016% and 0.08% when tested against human and monkey cell lines. Isoborneol specifically inhibited glycosylation of viral polypeptides based on the following data: (1) the mature fully glycosylated forms of two viral glycoproteins gB and go were not detected when the virus was replicated in the presence of isoborneol, (2) no major changes were observed in the glycosylation pattern of cellular polypeptides between untreated and isoborneol treated Vero cells, (3) isoborneol did not affect the glycosylation of gB produced from a copy of the gB gene resident in the cellular genome, and (4) other monoterpenes such as 1,8-cineole and borneol, a stereoisomer of isoborneol, did not inhibit HSV-I glycosylation. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：79 / 92

页数：14

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