Suppression of Mycobacterium tuberculosis induced reactive oxygen species (ROS) and TNF-α mRNA expression in human monocytes by allicin

被引：34

作者：

Hasan, Nazarul

Yusuf, Nabiha

Toossi, Zahra

Islam, Najmul ^{[1
]}

机构：

[1] Aligarh Muslim Univ, Coll Med, Fac Med, Dept Biochem, Aligarh 202002, Uttar Pradesh, India

[2] Univ Birmingham, Dept Dermatol, Birmingham, AL USA

[3] Case Western Reserve Univ, Dept Med, Div Infect Dis, Cleveland, OH 44106 USA

来源：

FEBS LETTERS | 2006年 / 580卷 / 10期

关键词：

allicin; TNF-alpha; glutathione peroxidase; NF-kappa B; reactive oxygen species;

D O I：

10.1016/j.febslet.2006.03.071

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic inflammation associated with tumor necrosis factor (TNF)-alpha and reactive oxygen species (ROS) is the hallmark of tuberculosis. Mycobacterium tuberculosis (MTB) directly stimulates human monocytes to secrete TNF-alpha. We show the augmented expression of TNF-alpha mRNA in MTB-infected monocytes by cellular activation and ROS was suppressed by allicin in a dose-dependent manner. Also, allicin enhanced the glutathione peroxidase activity, which correlated inversely with the downregulation of ROS and TNF-alpha in MTB-infected monocytes. Hence, allicin may prove to be a valuable natural antioxiant in combating tuberculosis. (c) 2006 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：2517 / 2522

页数：6

共 36 条

[1] Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica [J].