Metallo-β-lactamase:: structure and mechanism

被引：264

作者：

Wang, ZG ^{[1
]}

Fast, W ^{[1
]}

Valentine, AM ^{[1
]}

Benkovic, SJ ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, Davey Lab 152, University Pk, PA 16802 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 05期

关键词：

D O I：

10.1016/S1367-5931(99)00017-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This past year has produced determinations of X-ray crystal structures for three metallo-beta-lactamases and the elucidation of the catalytic mechanisms for a monozinc and a dizinc enzyme. These advances shed light on how such a diverse group of enzymes are evolving to inactivate so efficiently a broad spectrum of beta-lactam antibiotics.

引用

页码：614 / 622

页数：9

共 52 条

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