Directing T cell differentiation and function with small molecule inhibitors

被引：12

作者：

Bruno, Ludovica ^{[1
]}

Merkenschlager, Matthias ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, MRC Clin Sci Ctr, Lymphocyte Dev Grp, London, England

来源：

CELL CYCLE | 2008年 / 7卷 / 15期

基金：

英国医学研究理事会;

关键词：

regulatory T cell; signaling; differentiation; migration; homing;

D O I：

10.4161/cc.6444

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Regulatory T (Treg) cells that express the signature transcription factor Foxp3 safeguard against autoimmunity and immune pathology. Recent studies show that a signaling network with the components phosphatidyl inositol 3 kinase (PI3K), Akt, and the mammalian target of rapamycin (mTOR) regulates the de novo expression of Foxp3 in CD4 T cells. In addition to CD4 T cell differentiation, PI3K/Akt/mTOR signaling also controls T cell migration. Here we review the new data, consider their evolutionary context and discuss their potential implications for immunotherapy.

引用

页码：2296 / 2298

页数：3

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