Target Flexibility: An Emerging Consideration in Drug Discovery and Design

被引：232

作者：

Cozzini, Pietro ^{[1
,3
]}

Kellogg, Glen E. ^{[2
,4
]}

Spyrakis, Francesca ^{[1
,3
]}

Abraham, Donald J. ^{[1
]}

Costantino, Gabriele ^{[5
]}

Emerson, Andrew ^{[6
]}

Fanelli, Francesca ^{[7
]}

Gohlke, Holger ^{[8
]}

Kuhn, Leslie A. ^{[9
,10
,11
]}

Morris, Garrett M. ^{[12
]}

Orozco, Modesto ^{[13
]}

Pertinhez, Thelma A. ^{[14
]}

Rizzi, Menico ^{[15
]}

Sotriffer, Christoph A. ^{[16
]}

机构：

[1] Univ Parma, Dept Gen & Inorgan Chem, I-43100 Parma, Italy

[2] Virginia Commonwealth Univ, Dept Med Chem, Richmond, VA 23298 USA

[3] Natl Inst Biosyst & Biostruct, Rome, Italy

[4] Virginia Commonwealth Univ, Inst Struct Biol & Drug Discovery, Richmond, VA 23298 USA

[5] Univ Parma, Dept Pharmaceut, I-43100 Parma, Italy

[6] CINECA Supercomp Ctr, Bologna, Italy

[7] Univ Modena, Dulbecco Telethon Inst, Dept Chem, I-41100 Modena, Italy

[8] Univ Kiel, Dept Math & Nat Sci, Inst Pharmaceut, D-24118 Kiel, Germany

[9] Michigan State Univ, Dept Biochem & Mol Biol, E Lansing, MI 48824 USA

[10] Michigan State Univ, Dept Comp Sci & Engn, E Lansing, MI 48824 USA

[11] Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA

[12] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[13] Univ Barcelona, Dept Biochem & Mol Biol, Mol Modeling & Bioinformat Unit, Inst Biomed Res, E-08028 Barcelona, Spain

[14] Univ Parma, Dept Expt Med, I-43100 Parma, Italy

[15] Univ Piemonte Orientale Amedeo Avogadro, Dept Chem Food Pharmaceut & Pharmacol Sci, I-28100 Novara, Italy

[16] Univ Wurzburg, Inst Pharm & Food Chem, D-97074 Wurzburg, Germany

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 51卷 / 20期

关键词：

D O I：

10.1021/jm800562d

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

[No abstract available]

引用

页码：6237 / 6255

页数：19

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