Expression of 5-HT3 receptors in primary sensory neurons of the petrosal ganglion of adult rats

被引：14

作者：

Wang, ZY ^{[1
]}

Keith, IA

Olson, EB

Vidruk, EH

Bisgard, GE

机构：

[1] Univ Wisconsin, Dept Surg Sci, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Comparat Biosci, Madison, WI 53706 USA

[3] Univ Wisconsin, Dept Prevent Med, Madison, WI 53706 USA

来源：

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2002年 / 95卷 / 1-2期

关键词：

5-HT(3) receptor; petrosal ganglion; tyrosine hydroxylase; rat;

D O I：

10.1016/S1566-0702(01)00384-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

By using a specific antiserum, expression of the 5-HT(3) receptor was examined in the petrosal ganglion (PG) of adult male rats, We found that the 5-HT(3) receptors are widely distributed in the PG, This finding was confirmed by RT-PCR detection of the 5-HT(3) receptor mRNA in the tissue. Unlike the distribution patterns of tyrosine hydroxylase (TH), which occurred in limited regions of PG, the 5-HT(3) receptors seemed to distribute throughout the ganglion. As many TH-positive neurons in PG innervate type I cells in the carotid body, the coexistence of 5-HT(3) receptor and TH in some neurons suggests that this receptor may play a role in carotid body chemoreception. C 2002 Elsevier Science B.V. All rights reserved.

引用

页码：121 / 124

页数：4

共 20 条

[1] EFFECTS OF DOPAMINE, NOREPINEPHRINE AND 5-HYDROXYTRYPTAMINE ON THE CAROTID-BODY OF THE DOG [J].