Histamine reduces ZO-1 tight-junction protein expression in cultured retinal microvascular endothelial cells

被引：66

作者：

Gardner, TW ^{[1
]}

Lesher, T ^{[1
]}

Khin, S ^{[1
]}

Vu, C ^{[1
]}

Barber, AJ ^{[1
]}

Brennan, WA ^{[1
]}

机构：

[1] PENN STATE UNIV,COLL MED,DEPT CELLULAR & MOL PHYSIOL,HERSHEY,PA 17033

来源：

BIOCHEMICAL JOURNAL | 1996年 / 320卷

关键词：

D O I：

10.1042/bj3200717

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined ZO-1 protein content in cultured retinal vascular endothelial cells to test the hypothesis that histamine alters tight-junction-protein expression. Histamine (10(-8)-10(-4) M) causes a reversible concentration-dependent reduction of ZO-1 protein content, mediated by both H-1 and H-2 receptors. Histamine reduces ZO-1 expression within the time associated with increased paracellular permeability. Tight-junction-protein alterations may be a novel explanation for the mechanism by which vasoactive agents increase microvascular permeability.

引用

页码：717 / 721

页数：5

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