Celiac disease

被引:10
作者
Parnell, N [1 ]
Ciclitira, PJ [1 ]
机构
[1] St Thomas Hosp, UMDS, Gastroenterol Unit, London SE1 7EH, England
关键词
D O I
10.1097/00001574-199903000-00006
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
There continues to be much research interest in celiac disease, with well over 200 papers published in the year under review, covering a multitude of areas from population screening to the molecular immunology of disease pathogenesis. The high prevalence of "silent" disease again has been demonstrated, and there is continued emphasis on the increasingly wide recognized range of associated conditions and extraintestinal manifestations. The case for the safety of oats is further strengthened by a study involving patients with dermatitis hepetiformis. One of the most significant scientific advances has been the discovery of a potential role for tissue transglutaminase, recently found to be the autoantigen of antiendomysial antibodies, in disease pathogenesis, by enhancing gliadin peptide class II binding and consequent T-cell activation. However, the very central role of T cells has been thrown into doubt with an elegant study that assessed the effect of blocking costimulation in T-cell activation.
引用
收藏
页码:120 / 124
页数:5
相关论文
共 35 条
[1]  
Bardella MT, 1997, AM J GASTROENTEROL, V92, P1524
[2]   CELIAC-DISEASE IN THE YEAR 2000 - EXPLORING THE ICEBERG [J].
CATASSI, C ;
RATSCH, IM ;
FABIANI, E ;
ROSSINI, M ;
BORDICCHIA, F ;
CANDELA, F ;
COPPA, GV ;
GIORGI, PL .
LANCET, 1994, 343 (8891) :200-203
[3]   Abnormal intestinal intraepithelial lymphocytes in refractory sprue [J].
Cellier, C ;
Patey, N ;
Mauvieux, L ;
Jabri, B ;
Delabesse, E ;
Cervoni, JP ;
Burtin, ML ;
Guy-Grand, D ;
Bouhnik, Y ;
Modigliani, R ;
Barbier, JP ;
Macintyre, E ;
Brousse, N ;
Cerf-Bensussan, N .
GASTROENTEROLOGY, 1998, 114 (03) :471-481
[4]   High incidence and prevalence of adult coeliac disease - Augmented diagnostic approach [J].
Collin, P ;
Reunala, T ;
Rasmussen, M ;
Kyronpalo, S ;
Pehkonen, E ;
Laippala, P ;
Maki, M .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1997, 32 (11) :1129-1133
[5]   The smaller size of the 'coeliac iceberg' in adults [J].
Corazza, GR ;
Andreani, ML ;
Biagi, F ;
Corrao, G ;
Pretolani, S ;
Giulianelli, G ;
Ghironzi, G ;
Gasbarrini, G .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1997, 32 (09) :917-919
[6]  
Cronin CC, 1997, AM J GASTROENTEROL, V92, P2210
[7]   Coeliac disease and epilepsy [J].
Cronin, CC ;
Jackson, LM ;
Feighery, C ;
Shanahan, F ;
Abuzakouk, M ;
Ryder, DQ ;
Whelton, M ;
Callaghan, N .
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 1998, 91 (04) :303-308
[8]   Identification of tissue transglutaminase as the autoantigen of celiac disease [J].
Dieterich, W ;
Ehnis, T ;
Bauer, M ;
Donner, P ;
Volta, U ;
Riecken, EO ;
Schuppan, D .
NATURE MEDICINE, 1997, 3 (07) :797-801
[9]   Genome search in Celiac disease [J].
Greco, L ;
Corazza, G ;
Babron, MC ;
Clot, F ;
Fulchignoni-Lataud, MC ;
Percopo, S ;
Zavattari, P ;
Bouguerra, F ;
Dib, C ;
Tosi, R ;
Troncone, R ;
Ventura, A ;
Mantavoni, W ;
Magazzu, G ;
Gatti, R ;
Lazzari, R ;
Giunta, A ;
Perri, F ;
Iacono, G ;
Cardi, E ;
de Virgiliis, S ;
Cataldo, F ;
De Angelis, G ;
Musumeci, S ;
Ferrari, R ;
Balli, F ;
Bardella, MT ;
Volta, U ;
Catassi, C ;
Torre, G ;
Eliaou, JF ;
Serre, JL ;
Clerget-Darpoux, F .
AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (03) :669-675
[10]   Absence of toxicity of oats in patients with dermatitis herpetiformis [J].
Hardman, CMJ ;
Garioch, JJ ;
Leonard, JN ;
Thomas, HJW ;
Walker, MM ;
Lortan, JE ;
Lister, A ;
Fry, L .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (26) :1884-1887