Background and Purpose - To evaluate the effect of prism adaptation (PA) on spatial neglect signs. Methods - Ten patients (hemianopia in 6) and 8 control subjects were included. Tasks were reading single words, nonwords, and a text, bell cancellation, line bisection, and scene drawing, before and after adaptation, with either deviating or neutral prisms. Results - Errors were more frequent in patients but without any specific effect of PA. We found partial improvement at the late sessions, independent of prisms. Conclusions - We did not confirm the efficacy of PA on spatial neglect.