Alcohol Metabolism

被引：960

作者：

Cederbaum, Arthur I. ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA

来源：

CLINICS IN LIVER DISEASE | 2012年 / 16卷 / 04期

关键词：

Alcohol dehydrogenase; Cytochrome P4502E1; Acetaldehyde metabolism; Hepatic redox state; Alcohol absorption; Distribution and elimination; Isoforms of alcohol dehydrogenase; Metabolic adaptation to alcohol; MALATE-ASPARTATE SHUTTLE; ETHANOL-METABOLISM; RAT-LIVER; REDUCING EQUIVALENTS; GENDER-DIFFERENCES; 1ST-PASS METABOLISM; OXIDATIVE STRESS; REDOX STATE; PHARMACOKINETICS; DEHYDROGENASE;

D O I：

10.1016/j.cld.2012.08.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

This article describes the pathways and factors that modulate blood alcohol levels and metabolism and describes how the body disposes of alcohol. The various factors that play a role in the distribution of alcohol in the body, influence the absorption of alcohol, and contribute to first-pass metabolism of alcohol are described. Most alcohol is oxidized in the liver, and general principles and overall mechanisms for alcohol oxidation are summarized. The kinetics of alcohol elimination in-vivo and the various genetic and environmental factors that can modify the rate of alcohol metabolism are discussed.

引用

页码：667 / +

页数：20

共 75 条

[1]

Addolorato G, 1997, ALCOHOL CLIN EXP RES, V21, P962, DOI 10.1111/j.1530-0277.1997.tb04238.x

[2]

HUMAN ALDEHYDE DEHYDROGENASES - THEIR ROLE IN ALCOHOLISM [J].

AGARWAL, DP ;

GOEDDE, HW .

ALCOHOL, 1989, 6 (06) :517-523

[3]

Gender differences in pharmacokinetics of alcohol [J].

Baraona, E ;

Abittan, CS ;

Dohmen, K ;

Moretti, M ;

Pozzato, G ;

Chayes, ZW ;

Schaefer, C ;

Lieber, CS .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2001, 25 (04) :502-507

[4]

ALCOHOL METABOLISM IN AMERICAN INDIANS AND WHITES - LACK OF RACIAL DIFFERENCES IN METABOLIC-RATE AND LIVER ALCOHOL-DEHYDROGENASE [J].

BENNION, LJ ;

LI, TK .

NEW ENGLAND JOURNAL OF MEDICINE, 1976, 294 (01) :9-13

[5]

ROLE OF SODIUM-PUMP IN REGULATION OF LIVER METABOLISM IN EXPERIMENTAL ALCOHOLISM [J].

BERNSTEIN, J ;

VIDELA, L ;

ISRAEL, Y .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1974, 242 (NOV29) :560-572

[6]

The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine [J].

Bolt, HM ;

Roos, PH ;

Thier, R .

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 2003, 76 (03) :174-185

[7]

GENETIC-FACTORS IN ALCOHOL METABOLISM AND ALCOHOLISM [J].

BOSRON, WF ;

EHRIG, T ;

LI, TK .

SEMINARS IN LIVER DISEASE, 1993, 13 (02) :126-135

[8]

Swift increase in alcohol metabolism (SIAM): understanding the phenomenon of hypermetabolism in liver [J].

Bradford, BU ;

Rusyn, I .

ALCOHOL, 2005, 35 (01) :13-17

[9]

Oxidative stress, toxicology, and pharmacology of CYP2E1 [J].

Caro, AA ;

Cederbaum, AI .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2004, 44 :27-42

[10]

CHARACTERIZATION OF SHUTTLE MECHANISMS FOR TRANSPORT OF REDUCING EQUIVALENTS INTO MITOCHONDRIA [J].

CEDERBAU.AI ;

LIEBER, CS ;

BEATTIE, DS ;

RUBIN, E .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1973, 158 (02) :763-781

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