Tramadol distribution in four postmortem cases

被引:45
作者
Levine, B
Ramcharitar, V
Smialek, JE
机构
[1] Office of the Chief Medical Examiner, Baltimore, MD 21201
关键词
tramadol; postmortem; opioid;
D O I
10.1016/S0379-0738(97)02111-7
中图分类号
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号
0301 ; 10 ;
摘要
Four postmortem cases are reported in which the analgesic drug tramadol was identified. Tramadol is an alkaline extractable drug and elutes from a HP-5 column without the need for derivatization. Two metabolites of tramadol, N-desmethyl and O-desmethyl tramadol were also identified. Heart blood concentrations of tramadol in the four cases ranged from 0.17 to 4.4 mg/l. Tissue distribution of tramadol in the four cases failed to identify a sequestration site. None of the deaths reported were attributed to tramadol intoxication. (C) 1997 Elsevier Science Ireland Ltd.
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页码:43 / 48
页数:6
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